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Bloodline - Hematology Education and News

Case Reports
Immunotherapy with Rituximab for Antiphospholipid Syndrome
This is a case report of a patient given rituximab immunotherapy with continued warfarin for warfarin resistant disease, with improvement in the concentrations of the involved antibodies and the clinical syndrome. This report gives a signal for the activity of this form of immunotherpay in treating aggressive versions of the antiphospholipid syndrome.
 
A Case of Hereditary Elliptocytosis
Here are three images from peripheral blood smear from a patient with Hereditary Elliptocytosis.The patient presented for a general check up when his CBC showed only mild anemia with slightly increased reticulocytes. The diagnosis was made incidentally when blood smear was examined.
 
Lymphoid Blast Crisis in m-BCR-Positive CML
We report a case of a 69-year-old woman presenting with CML in lymphoid blast crisis who had an m-BCR breakpoint and a bone marrow showing myeloproliferative features such as increased granulopoiesis and megakaryopoiesis with focal fibrosis and an increased number of blasts.
 
Large Platelets in a Trauma Patient
This trauma patient was a 72 year-old male with aortic and mitral valve prostheses under chronic anticoagulation therapy with warfarin. He was admitted to the Trauma Unit with a ruptured spleen and acute blood loss. Splenectomy and blood transfusions were required.
 
Homozygous sickle cell disease in a 28 year old female
This patient was a 28 year old female with a long-standing history of sickle cell anemia. She has suffered multiple episodes of vaso-occlusive crises, requiring hospitalization. Having received multiple transfusions during her lifetime, this patient has been treated with iron-chelating agents for iron overload.
 
Multiple Autoimmune Dysfunction Presenting as Atypical ITP
This case report illustrates how immune-mediated thrombocytopenia can be a presenting sign of a more global underlying autoimmune disorder.
 
Massive Hemolysis and Methemoglobinemia in a Toddler
This case report illustrates the clinical severity that can occur when potent oxidizers induce methemoglobinemia and hemolysis in G6PD deficient patients.
 

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